A New Control Strategy for Photovoltaic System Connected to the Grid via Three-Time-Scale Singular Perturbation Technique with Performance Analysis

This chapter addresses the problem of controlling single-phase grid-connected photovoltaic system through a full bridge inverter with L-filter. The control objectives are threefold: (i) forcing the voltage in the output of photovoltaic panel to track a reference. This reference has been obtained from the maximum power point tracking strategy; (ii) guaranteeing a tight regulation of the DC-link voltage; and (iii) ensuring a satisfactory power factor correction (PFC) at the grid such as the currents injected must be sinusoidal with the same frequency and the same phase as the grid voltage. The considered control problem entails several difficulties including: (i) the high dimension and strong nonlinearity of the system; (ii) the changes in atmospheric conditions. The problem is dealt with by designing a synthesized nonlinear multi-loop controller using singular perturbation technique, in which a three-time-scale dynamics is artificially induced in the closed-loop system. A formal analysis based on the three-time-scale singular perturbation technique and the averaging theory is developed to proved that all control objectives are asymptotically achieved up to small harmonic errors (ripples). The performance of the proposed approach and its strong robustness with respect to climate changes are evaluated based on the various simulations results carried out under Matlab/Simulink software

Biological, toxicological and molecular docking evaluations of isoxazoline-thiazolidine-2,4-dione analogues as new class of anti-hyperglycemic agents

In this work, three isoxazoline-thiazolidine-2,4-dione derivatives were synthesized and characterized by FT-IR, 1H-NMR, 13C-NMR and ESI-MS spectrometry. All compounds have been investigated for their α-amylase and α-glucosidase inhibitory activities. In vitro enzymatic evaluation revealed that all compounds were inhibitory potent against α-glucosidase with IC50 values varied from 40.67 ± 1.81 to 92.54 ± 0.43 µM, and α-amylase with IC50 in the range of 07.01 ± 0.02 to 75.10 ± 1.06 µM. One of the tested compounds were found to be more potent inhibitor compared to other compounds and standard drug Acarbose (IC50 glucosidase= 97.12 ± 0.35 µM and IC50 amylase= 2.97 ± 0.01 μM). All compounds were then evaluated for their acute toxicity in vivo and shown their safety at a high dose with LD > 2000mg/kg BW. A cell-based toxicity evaluation was performed to determine the safety of compounds on liver cells, using the MTT assay against HepG2 cells, and the results shown that all compounds have non-toxic impact against cell viability and proliferation compared to reference drug (Pioglitazone). Furthermore, the molecular homology analysis, SAR and the molecular binding properties of compound with the active site of α-amylase and α-glucosidase were confirmed through computational analysis. This study has identified the inhibitory potential of a new class of synthesized isoxazoline-thiazolidine-2,4-dione derivatives in controlling both hyperglycemia and type 2 diabetes mellitus without any hepatic toxicity.Communicated by Ramaswamy H. Sarma.Authors thank all collaborators for their constant support and encouragement.Peer reviewe

Chemical Profile, Antibacterial and Antioxidant Potential of Zingiber officinale Roscoe and Elettaria cardamomum (L.) Maton Essential Oils and Extracts

The aim of this work was to study the chemical composition of the essential oil extracted from ginger rhizomes (Zingiber officinale Roscoe) and cardamom seeds (Elettaria cardamomum (L.) Maton). Using gas chromatography coupled with mass spectrometry (GC/MS), a total of 43 compounds were identified in ginger essential oil and 17 compounds in cardamom. The most abundant components, respectively, were zingiberene (22.18%) and 1.8-cinéol (43.47%). Essential oils, methanol, ethanol and chloroform extracts for both plants were tested against nine bacteria and yeast. The highest sensitivity was noticed against Staphylococcus aureus with a 25 mm inhibition zone. The antioxidant potency of both oils and extracts were measured using DPPH (1,1-diphenyl-2-picryl hydrazyl) free radical scavenging and the ferric reducing power (FRP) method; the ethanolic extract of cardamom fruits exhibited the best results for both tests, with an IC 50 = 0.423 ± 0.015 mg/mL and 95.03 ± 0.076 FRP mg AAE/g